The research group of Prof. Dr. Christiane Zweier at the Institute of Human Genetics focuses on the clinical, genetic and functional characterization of neurodevelopmental disorders and intellectual disability. During recent years, the role of proteasomal degradation in cognitive function and dysfunction has been increasingly recognized.
The proposed PhD project is embedded in a DFG-funded research training group (GRK2162) and focuses on a protein involved in protein ubiquitination and proteasomal degradation that is mutated in a severe epileptic encephalopathy. Aims of the project include the delineation of genotype-phenotype correlations and the functional characterization of the protein in proteasomal degradation and in cognitive function and dysfunction. Substrate proteins, interaction partners and involved pathways will be identified using proteomic and transcriptomic approaches with the help of the model organism Drosophila melanogaster and cell-based assays using induced pluripotent stem cells.
Successful applicant will receive the following benefits:
- A 03 year structured PhD program with interdisciplinary thesis research
- A vibrant, collaborative scientific environment
- Supervision and mentorship by a team of internationally renowned experts
- State-of-the-art research facilities
- Advanced training opportunities (scientific, skills, career) in English
To be eligible for PhD Scholarships, an applicant must:
- Hold a Master Degree in Biomedical or Molecular Sciences or Biology, preferably with background knowledge in Neurobiology and/or Genetics
- Expertise in protein turnover or bioinformatics would be advantageous
- Highly motivated, interactive and team-oriented with a high degree of self-initiative and inventiveness
To apply for Fully Funded PhD Scholarships Position in Human Genetics, an applicant must submit following documents with application:
- A detailed Curriculum Vitae
- High school and university diploma
- Description of research experience including applied methodologies
- Two letters of recommendation or contact information of two references
- List of publications, if available
Applications should be sent in one pdf file per e-mail to:
Qualified women are strongly encouraged to apply. Applications of disabled persons with equal qualifications will be treated preferentially.